Latest Forum Topics /
Clearbridge
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Medical Stock - Strong Shareholders
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WBdisciple
Elite |
29-Nov-2019 21:54
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Clearbridge serves close to 4 million patients per year with a Public-Private-Partnership Model in Indonesia Adopting a Public-Private-Partnership Model to scale its healthcare services operations in Indonesia, Clearbridge currently manages a total of 49 hospital joint operation contracts (&ldquo JOs&rdquo ) in Indonesia serving close to 4 million patients per year, primarily in the area of renal care (through PT Tirta Medika Jaya (&ldquo TMJ&rdquo ) which was acquired in April 2018) and pathology (through PT Indo Genesis Medika (&ldquo IGM Labs&rdquo ) which was acquired in May 2019) at public and private hospitals (ranging from Class A to Class C) in Indonesia.  The renal care services and laboratory testing services offered by TMJ and IGM Labs are reimbursed through the Indonesia health coverage program. TMJ is currently operating 21 renal care centres under JO with hospitals in Indonesia. In addition, there are another 16 renal care centres that are currently under construction, with the potential of revenue contribution once they are completed progressively.  For IGM Labs, it is operating 12 diagnostics laboratories with another JO Contract that is in the process of being novated to IGM Labs. Undertaking more than 7 million pathology tests a year, IGM Labs has diagnostics laboratories in 6 of the largest Class A hospitals, out of 16 Class A hospitals in Indonesia.  To promote the adoption of precision medicine in Indonesia, the Group will be introducing healthcare solutions and technologies from its medical technologies companies into these JOs. - Revenue increased by more than 2 folds in 3Q2019 with the contributions from the acquisitions of IGM Labs and nine dental clinics that were completed in May 2019 and August 2019 respectively  - Validating the Group&rsquo s EBITDA-focused strategy, the Group&rsquo s 3Q2019 revenue of S$6.39 million is almost on par with its first half revenue of S$6.85 million  - As of 30 September 2019, the Group&rsquo s financial position remained healthy with total assets increasing to S$99.92 million with cash at banks and short-term deposits of S$15.10 million. |
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WBdisciple
Elite |
25-Nov-2019 22:03
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Another showcase of the potential of precision medicine..
Chinese parents test DNA to check if kids will become prodigieshttps://www.straitstimes.com/asia/east-asia/chinese-parents-test-dna-to-check-if-kids-will-become-prodigies |
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jarp178
Member |
14-Nov-2019 19:09
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Positive EBITDA but still lmaking losses.. isit a good or bad thing? the report also did not mentioned a thing about whether their business is affected by the hk riot... or did i missed it...
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WBdisciple
Elite |
14-Nov-2019 19:05
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Clearbridge Continues its Strong Growth Momentum Quarterly Revenue Jumps 211.5% to a Record S$6.39 Million in 3Q2019  https://links.sgx.com/1.0.0/corporate-anno...  &bull Revenue increased by more than 2 folds in 3Q2019 with the contributions from the acquisitions of IGM Labs and nine dental clinics that were completed in May 2019 and August 2019 respectively  &bull Validating the Group&rsquo s EBITDA-focused strategy, the Group&rsquo s 3Q2019 revenue of S$6.39 million is almost on par with its first half revenue of S$6.85 million  &bull Excluding fair value losses in associate and derivative financial instruments & non-recurring operating expenses, the Group has recorded positive EBITDA of S$0.38 million in 3Q2019 It is worth noting that the fair value losses related to associate and derivative financial instruments are non-cash components. As of 30 September 2019, the Group&rsquo s financial position remained healthy with total assets increasing to S$99.92 million with cash at banks and short-term deposits of S$15.10 million. Commenting on the 3Q2019 results, Mr Jeremy Yee (余 斌 ), Executive Director and Chief Executive Officer of Clearbridge, said, &ldquo Our record revenue achieved in this quarter reinforces the coherence of our EBITDA-focused business strategy and strong operational execution. We have made substantial progress in the execution of our strategic priorities to build unique value propositions in high-growth healthcare segments in Asia. With our strategic focus in precision medicine, 2019 will be another step forward in our commitment to deliver sustainable profitable growth.&rdquo |
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383838
Senior |
14-Nov-2019 17:52
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Closed at today's HAI coupled with heavy volume. Hopefully got something goose. Best tmr gap up above fivety . | ||
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Trexxx
Veteran |
14-Nov-2019 17:46
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why so quiet here. party just started
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383838
Senior |
14-Nov-2019 17:08
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Wanau eh! This bridge today so strong n done so much. Shiok man. In out in out shiok man. In 41 out 47. In 44 again. But havent out. Tmr lah. Hehehehehe!!!!!!! | ||
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Trexxx
Veteran |
14-Nov-2019 09:47
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still a seed. dont wait for leaf to appear and chase
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383838
Senior |
14-Nov-2019 09:40
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This bridge is coming | ||
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WBdisciple
Elite |
11-Nov-2019 09:15
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3 Cancer Treatment Stocks to Buy Right Now
  The Motley Fool
 
Now is a great time to have biotech stocks in your portfolio. While biotech investing can be scary, because the small-cap companies are often unprofitable research-and-development labs, this is also where a lot of the cutting-edge science is happening.
 
Let' s see how Mirati Therapeutics (NASDAQ: MRTX), Iovance Biotherapeutics (NASDAQ: IOVA), and Personalis (NASDAQ: PSNL) are all using gene therapy in the fight against cancer.
 
1. Using genetic research to inhibit the genes responsible for cancer growth
 
Mirati Therapeutics is in a race with Amgen (NASDAQ: AMGN) to find a drug that successfully inhibits KRAS mutations. KRAS is a gene in our bodies that has been identified as a cause of multiple cancers. Right now one of Mirati' s drugs is targeting a specific sub-mutation identified as KRAS G12C. This genetic malfunction is seen in 14% of non-small cell lung cancers, 5% of colon cancers, and 2% of pancreatic cancers. The company' s drug is an attempt to shut down this mutated gene so it will stop producing cancer cells.
 
Investors who want to play it safe might want to invest in Amgen, not Mirati Amgen is also pursuing drugs to inhibit the KRAS mutations. However, Amgen is a highly profitable, $130 billion megacap biotech with multiple drugs in clinical trials. If its KRAS program fails, Amgen' s stock will take a minor hit and the company will continue onwards and upwards. On the other hand, if Amgen and Mirati are both right about the importance of KRAS genes, then Mirati shareholders are likely to see far bigger returns on their investments. With the smaller biotech, the risk is higher but the rewards are greater.
 
Mirati is a $4 billion small cap with extensive knowledge of KRAS. Failure here would be brutal to the stock. On the other hand, any success would boost the stock into the stratosphere. So far, investors in Mirati have been winning big. Amgen has returned 56% to investors over the last five years, slightly underperforming the S& P 500, but tiny Mirati has returned 523%.
 
2. Using the body' s own immune system to destroy cancers
 
Iovance Biotherapeutics is introducing a novel way to fight against cancer. The company relies upon medicine that is specialized for each patient. When a cancer starts attacking your body, your system starts producing lymphocytes that are designed to infiltrate and attack the tumor. Cancer cells adopt and mutate to avoid destruction.
 
What Iovance does is remove some of these cancer-fighting agents, referred to as tumor-infiltrating lymphocytes (TILs), from your body. The company' s technology amplifies and multiplies these cells in the lab, creating billions of them. Then your own cancer-fighting agents are injected back into your body.
 
Iovance is running a phase 3 trial trial for Lifileucel, its treatment for skin cancer. But what' s causing the most excitement is LN-145, which is being tested on multiple cancers. The company is running a phase 3 trial for cervical cancer, and a phase 2 trial for head and neck cancers. Also, MD Anderson Cancer Network is running a phase 2 test on LN-145 for ovarian cancer and sarcoma.
 
The stock took off after it was reported that LN-145 had a 44% overall response rate against cervical cancer, and Lifileucel had a 38% overall response rate against melanoma. Iovance is a $2.72 billion small cap. It has $400 million in cash, $12 million in debt, and no revenue. So far in 2019 it' s returned 132% to investors.
 
3. Mapping 20,000 genes in 775,000 people
 
Personalis is developing the NeXT platform, a hugely ambitious undertaking that is mapping approximately 20,000 genes in the human body. Spun out of Stanford University, the company has a contract with the U.S. Department of Veterans Affairs. The federal agency is providing it the DNA information of over 775,000 veterans, so with this data, Personalis is mapping over 15 billion human genes. With all these volunteers, it' s developing a massive library of genetic data. Biotechs that subscribe to its service can access this information as they design cancer-fighting drugs in the lab.
 
The company' s immediate market is all the biotech companies doing cancer research. Using its library, subscribers can find cancer targets and design specific drugs to suppress the mutating genes that spread cancer in human beings. Right now Personalis has over 45 biopharma subscribers to its service. The company estimates this is a $5 billion market opportunity.
 
Next year Personalis hopes to compete in the $14 billion market of cancer diagnostics. It will offer its own liquid biopsy designed to detect cancer, and compete with Guardant Health (NASDAQ: GH), as well as NantHealth, Grail (a start-up funded in part by Jeff Bezos and Bill Gates), Thrive (a start-up spun out of Johns Hopkins), and others. We don' t yet know how much Personalis will charge for its biopsy, or how successful it will be.
 
But what we do know is that right now the company is a lot cheaper than its market-leading peer:
 
COMPANY      REVENUE GROWTH      P/S RATIO      MARKET CAP      STOCK PRICE CHANGE SINCE IPO
Guardant Health      181%      32      $6.75 billion      146%
Personalis      79.8%      6      $325 million      (65%)
Data source: Bloomberg and Yahoo Finance. P/S = price to sales IPO = initial public offering.
 
The market appears to be taking a wait-and-see attitude toward Personalis certainly there' s no excitement right now about its shares. That might change when its liquid biopsy is introduced next year.
 
In the meantime, Personalis is developing a very impressive library of knowledge of the human genome. Maybe one day the company will be competing with 23andme to provide personalized medicine to individuals (a market estimated to be worth $40 billion). It' s definitely a stock to keep an eye on, as the future looks bright.
 
Taylor Carmichael owns shares of Iovance Biotherapeutics. The Motley Fool owns shares of and recommends Guardant Health. The Motley Fool recommends Amgen. The Motley Fool has a disclosure policy.
 
The views and opinions expressed herein are the views and opinions of the author and do not necessarily reflect those of Nasdaq, Inc.
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WBdisciple
Elite |
11-Nov-2019 09:13
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Chinese oncology drug developer Tot Biopharm raises $75.2m in HK IPO  Tot Biopharm, a Chinese clinical-stage biopharma firm specialized in innovative oncology drugs and therapies, has raised about $75.2 million in an initial public offering (IPO) on the main board of the Hong Kong stock exchange on Friday. The biopharma company offered 90 million shares at a price of HK$6.55 apiece, the lower end of the proposed price range between HK$7.55 and HK$6.55.  Taipei Exchange-listed oral pharmaceutical business Centerlab, Vivo Capital, which invests in the healthcare industry in China and the United States, and Nien Hsing BVI, a wholly-owned subsidiary of Taiwan-based Nien Hsing Textile, served as cornerstone investors subscribing to $20 million worth shares in the IPO.  The listing came about six months after the Suzhou-based Tot Biopharm filed a prospectus with the stock exchange in early May 2019. The company applied to float shares in Hong Kong under rules that allow the listing of pre-profit biotech companies &ndash a new regime that came into effect on April 30, 2018 as authorities of the global financial hub seek to capitalize on opportunities from the up-and-coming biotech firms, which make up a majority of pre-revenue companies seeking an IPO.  The listing reform led to the highest fundraising record on the Hong Kong stock exchange in eight years, reclaiming the city&rsquo s crown as the top 1 IPO market worldwide in 2018 with 125 companies raising $36.5 billion in the year, according to Refinitiv data. Tot Biopharm, founded in 2009, recorded accumulated losses of 753.8 million yuan ($108 million) in 2018, up 55.3 per cent from 485.5 million yuan ($70 million) in 2017, according to its prospectus. The losses further increased by 13.6 per cent to 856.1 million yuan ($123 million) as of April 30, 2019, primarily attributable to increases in research and development expenses in relation to the clinical trials and pre-clinical development of drug candidates.  Tot Biopharm&rsquo s portfolio includes monoclonal antibodies, antibody-drug conjugates, oncolytic virus products and speciality oncology drugs such as liposome drugs, targeting various types of cancers. Its pipeline consists of seven biological and five chemical drug candidates, 11 of which are in-house developed. At present, four biological drug candidates of Tot Biopharm are in the clinical stage. TAB008, the core product of Tot Biopharm, is an anti-VEGF mAb and biosimilar drug candidate to bevacizumab, a medication used for the treatment of a number of cancers. The product will serve the Chinese bevacizumab market, which is projected to grow to 13.1 billion yuan ($1.88 billion) in 2023 with a compound annual growth rate (CAGR) of 32.7%, according to Frost & Sullivan. TAB008 is undergoing Phase III clinical trials in China, and is expected to be launched between the end of 2020 and early 2021, subject to regulatory approval. The company plans to use the net proceeds from the IPO to conduct clinical trials on drug candidates, and to expand sales and marketing staff in preparation for their approval and commercialization. Tot Biopharm has so far raised a total of $108 million across two funding rounds. It raised $6 million in a Series A round led by Chengwei Capital in 2010 and another $102 million in a Series B round in 2018, co-led by 99Fund and China Universal. |
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trademaster
Supreme |
23-Oct-2019 16:22
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always last to move... | ||
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trademaster
Supreme |
16-Oct-2019 15:55
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Short term resistance 149, target 159
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trademaster
Supreme |
16-Oct-2019 10:00
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Good news for Clearbridge | ||
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easywin
Supreme |
10-Oct-2019 12:22
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Can this " Clearbridge" able to fully cleared all obstacles as per her name? | ||
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watashievil
Master |
10-Oct-2019 11:28
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Sold le hopefully can buy again @ 141 or 137~ | ||
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trademaster
Supreme |
10-Oct-2019 10:25
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Looks like another round of push up and got  shorted at 147 | ||
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SgYuan
Supreme |
04-Oct-2019 09:08
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day chart ew 137 150 ?138
w1 13 w2 12 - px amost reset ew - px cannot break 137 - px need to break up 143.5 baseline resistance - then w3 cm w3 21 tgt 159 |
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WBdisciple
Elite |
03-Oct-2019 06:50
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Tapping healthcare opportunity in Asia via private equityTHU, OCT 03, 2019 - 5:50 AM
ASIA' S historically underinvested and overstretched healthcare systems are transforming to meet demand from growing and wealthier populations. Therefore, Asia' s healthcare market is growing at double-digit percentage rates, outpacing single-digit growth globally. By 2024, Asia' s healthcare market size will reach US$4.2 trillion, larger than the current US and European markets combined. Public healthcare financing falls short of plugging the annual US$60 billion funding gap. Asian governments, aware of budget constraints, are welcoming more private-sector involvement. Today, of every 10 new hospital beds built in Asia, seven are funded by the private sector. The depth and efficiency of private capital are now essential forces in improving healthcare quality and enabling innovation in the region. Opportunities have emerged for investors to not only secure superior returns, but also create sustainable and affordable healthcare for Asia. For example, chronic diseases associated with more affluent lifestyles are increasingly common. Yet, most Asians today pay out of their pockets for healthcare, as insurance coverage is still low and universal healthcare, where present, is largely underfunded. As a result, onerous healthcare costs have left many in financial ruin.    
 
  However, innovative and scalable business models can substantially lower costs without compromising on quality. The Asian Institute of Gastroenterology in India is one such example. With a focus on economies of scale and process efficiency, the gastric sciences hospital sees over 150,000 patients yearly, offering highly affordable healthcare with a level of quality comparable to prestigious institutions in the US. All this is anchored on its 700-bed hospital in Hyderabad, developed through a partnership with Quadria Capital, an independent healthcare private equity fund in Asia.    
 
  In Indonesia, Quadria Capital has helped SOHO Global Health to become one of the very few domestic pharmaceutical companies compliant with international standards such as US FCPA and UK ABAC. This has spurred the growth of an in-licensing platform that brings critical, life-saving drugs to low- and middle-income patients across Indonesia at a fraction of the cost compared to developed markets. Exceptional growth in the healthcare sector has not gone unnoticed in Asia. Market capitalisations of healthcare stocks have grown by 4.4 times in emerging Asia and 3.8 times in developed Asia over the last 10 years. Some of the biggest publicly-listed firms in the Asian healthcare sector are trading at high earnings multiples, lifting valuation expectations for private firms. The healthcare private equity sector is thus enjoying significant inflows. VALUE PROPOSITION Private deal volumes surged from 61 in 2017 to 88 in 2018, while disclosed value more than doubled from US$7.2 billion to US$15.8 billion. Deals ranged from seed funding investments to privatisations of large public entities. Private equity investing is often longer-term and illiquid. Capital calls make it challenging for investors to manage cash flows. Still, investors recognise that private equity is where the sweet spot lies in capturing healthcare opportunities in Asia. However, it takes more than just money to capture these opportunities. Expertise, network and experience also matter. Many market-leading healthcare companies with exceptional growth and an impactful value proposition are privately held. They span sectors like healthcare delivery, life sciences and associated healthcare services. These market leaders tend to be cash-rich and are not looking for pure financing deals. Rather, they are looking for strategic partners with a combination of operational and commercial healthcare expertise and international networks that can enable them to innovate further and access new markets. Only a handful of Asian healthcare private equity managers can help them. They tend to be managers who have created value through identifying and investing in successful market leaders and, by doing so, have developed an ecosystem of proprietary relationships. In turn, this ecosystem has become a source of more exclusive investment opportunities. With the right partners, investors can capture the transformational growth in Asian healthcare, showcasing how private equity and innovation can come together to benefit the public good. |
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watashievil
Master |
24-Sep-2019 11:29
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caught 50 lots dropping knife @0.141~ anyone wif me? | ||
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